NEUROFIBRILLARY DEGENERATION

OUR RESEARCH FOCUSES ON THE DRIVERS AND MECHANISMS OF NEUROFIBRILLARY TANGLE FORMATION AND TOXICITY IN NEURODEGENERATIVE DISORDERS.  WE ARE USING STATE-OF-THE-ART BIOCHEMICAL, MOLECULAR, AND GENETIC APPROACHES TO UNLOCK THE SECRETS OF DEVASTATING BRAIN DISEASES ​ 

Research overview

Our research focuses on the molecular neuropathology of neurodegenerative diseases. Using an interdisciplinary approach, we are unravelling the molecular changes occurring in diseases with neurofibrillary tangles composed of the tau protein (i.e., tauopathies).  This diverse set of brain diseases includes dementias, such as Alzheimer's disease, movement disorders, such as Parkinson's disease and related conditions, and the long-term sequelae of repetitive traumatic brain injury, or chronic traumatic encephalopathy. We are using histological, genetic, biochemical and molecular approaches to pinpoint underlying molecular and cellular triggers of these diseases. Recently, we have begun to deploy powerful artificial intelligence (machine learning)-based approaches, including computer vision, which is revolutionizing our approach to neurodegeneration. Major ongoing NIH-funded projects in the laboratory include:

  • Clinical, histopathological, biochemical and genetic studies of primary age-related tauopathy (R01NS095252)
  • Regulation of tau expression in Alzheimer's disease and aging (R01AG054008)
  • Clinicopathological studies of chronic traumatic encephalopathy (R01AG062348)
  • ​Clinicopathological studies of age-related neurodegeneration in HIV/AIDS (RF1AG060961)

Job opportunities


We have a number of opportunities for trainees of all levels from volunteers, to research technicians, masters students, graduate students, and post-doctoral fellows.

"IT IS FAIR TO SAY THAT, IN GENERAL, NO PROBLEMS HAVE BEEN EXHAUSTED; INSTEAD, MEN HAVE BEEN EXHAUSTED BY THE PROBLEMS."

                                                                                            -- SANTIAGO RAMON Y CAJAL

John Crary, MD-PhD

Principal Investigator


Dr. Crary obtained his MD and PhD from the State University of New York Downstate Medical Center and conducted is neuropathology training at Columbia University Medical Center ...