Dr. Crary, a Brooklyn native, went to high school at Saint Ann's School. Subsequently, he went to college at Brown University and majored in neuroscience. This is where he fell in love with brain research, conducting a project looking at NMDA mediated pain processing in the trigeminal system with Dr. David Bereiter. Later, he received is MD-PhD from SUNY Downstate Medical Center, working under Drs. Todd Sacktor (Neurology/Pharmacology) and Suzanne Mirra (Pathology). It is at this time that he developed a strong interest in the neuropathology of Alzheimer's disease, particularly neurofibrillary type degeneration. His thesis research highlighted a unique pattern of neurofibrillary degeneration in the limbic system that is associated with an atypical protein kinase C isoform. Later, Dr. Crary did his residency and fellowship training in neuropathology at Columbia University Medical Center and stayed on as an assistant professor under the mentorship of Dr. Michael Shelanski. Here, he conducted seminal work that led to the description of primary age-related tauopathy (PART). In 2014, Dr. Crary established a new neuropathology laboratory at Mount Sinai to continue this work and expand it to other neurodegenerative tauopathies, including chronic traumatic encephalopathy and progressive supranuclear palsy. Dr. Crary has numerous federal and foundation grants to study these diseases. Dr. Crary is a member of the editorial board of Acta Neuropathological and is a frequent contributor to the Tau Consortium.